Two Distinct Mechanisms Leading to Loss of Virological Control in the Rare Group of Antiretroviral Therapy-Naive, Transiently Aviremic Children Living with HIV-Reference-Cited by-同舟云学术

Two Distinct Mechanisms Leading to Loss of Virological Control in the Rare Group of Antiretroviral Therapy-Naive, Transiently Aviremic Children Living with HIV

Published:2022-01-26 Issue:2 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Vieira Vinicius A.¹^ORCID,Adland Emily¹,Grayson Nicholas E.¹,Csala Anna¹,Richards Fa’eeda²,Dacon Cherrelle³,Athavale Rohin¹,Tsai Ming-Han¹,D’Souza Reena¹,Muenchhoff Maximilian⁴⁵,Bonsall David⁶⁷^ORCID,Jooste Pieter²,Goulder Philip J. R.¹⁸

Affiliation:

1. Department of Paediatrics, University of Oxford, Oxford, United Kingdom

2. Department of Paediatrics, Kimberley Hospital, Kimberley, South Africa

3. Antibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA

4. Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, LMU München, Munich, Germany

5. German Center for Infection Research, Munich, Germany

6. Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

7. Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

8. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

Abstract

Very early initiation of antiretroviral therapy (ART) in pediatric HIV infection offers a unique opportunity to limit the size and diversity of the viral reservoir. However, only rarely is ART alone sufficient to achieve remission.

Funder

HHS | National Institutes of Health

Wellcome

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01535-21

Reference55 articles.

1. Estimated Timing of Mother-to-Child Human Immunodeficiency Virus Type 1 (HIV-1) Transmission by Use of a Markov Model

2. Early Initiation of Combination Antiretroviral Therapy in HIV-1-Infected Newborns Can Achieve Sustained Virologic Suppression With Low Frequency of CD4+ T Cells Carrying HIV in Peripheral Blood