Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile-Reference-Cited by-同舟云学术

Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile

Published:2019-11-27 Issue:520 Volume:11 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Garcia-Broncano Pilar¹^ORCID,Maddali Shivaali¹^ORCID,Einkauf Kevin B.¹²^ORCID,Jiang Chenyang¹²^ORCID,Gao Ce¹^ORCID,Chevalier Joshua¹²^ORCID,Chowdhury Fatema Z.¹^ORCID,Maswabi Kenneth³,Ajibola Gbolahan³^ORCID,Moyo Sikhulile³^ORCID,Mohammed Terence³,Ncube Thabani³,Makhema Joseph³,Jean-Philippe Patrick⁴,Yu Xu G.¹²⁵^ORCID,Powis Kathleen M.³⁵⁶⁷,Lockman Shahin²³⁵^ORCID,Kuritzkes Daniel R.²⁵,Shapiro Roger³⁵⁷^ORCID,Lichterfeld Mathias¹²⁵^ORCID

Affiliation:

1. Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.

2. Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.

3. Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.

4. Division of AIDS, NIAID, NIH, Rockville, MD 20852, USA.

5. Harvard Medical School, Boston, MA 02115, USA.

6. Departments of Medicine and Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA.

7. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Abstract

Antiretroviral treatment initiation immediately after birth reduces HIV-1 viral reservoir size and alters innate immune responses in neonates.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference75 articles.

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2. http://aidsinfo.unaids.org/.

3. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis

4. Early Antiretroviral Therapy and Mortality among HIV-Infected Infants

5. World Health Organization Antiretroviral Therapy for HIV Infection in Infants and Children: Towards Universal Access—Recommendations for a Public Health Approach: 2010 Revision (World Health Organization 2010); www.who.int/hiv/pub/paediatric/infants2010/en/index.html.

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