Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition-Reference-Cited by-同舟云学术

Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition

Published:2021-09-24 Issue:10 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Yao Tao¹^ORCID,Zhang Lei¹,Fu Ye¹,Yao Lina¹,Zhou Chengjie¹,Chen Guozhong¹

Affiliation:

1. Department of Critical Care Medicine, The Affiliated People's Hospital of Ningbo University, Ningbo, People’s Republic of China

Abstract

Evidence exists reporting that saikosaponin-d can prevent experimental sepsis, and this study aims to illustrate the molecular events underlying its renoprotective effects on lipopolysaccharide (LPS)-induced renal inflammation simulating sepsis. Through network pharmacology analysis and bioinformatics analysis, we identified that saikosaponin-d may influence sepsis development by mediating TCF7.

Funder

Zhejiang Provincial Medical and Health Science and Technology Program

Ningbo Medical Science and Technology Program

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00332-21

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