Affiliation:
1. Department of Oral Biology, University of Florida, Gainesville, Florida 32610
Abstract
ABSTRACT
We have previously shown that
Salmonella enterica
serovar Typhimurium expressing the
hagB
hemagglutinin gene from
Porphyromonas gingivalis
can induce primary and recall immune responses in serum and secretions in mice; however, the longevity of memory induced by oral
Salmonella
carriers has not been adequately demonstrated. In this study, we examined the capacity of mice to mount a recall response 52 weeks after primary immunization. Recall responses were seen in serum immunoglobulin G (IgG) and IgA following boosting at week 52, and in most cases, they were equal to or greater than the primary responses. Significant mucosal IgA recall responses in saliva and vaginal wash were also detected following boosting at week 52. In addition, there was a considerable residual response in secretions at week 51, prior to boosting. These results indicate that oral
Salmonella
vectors can induce long-term memory to recombinant HagB and are particularly effective at inducing long-lasting mucosal responses as well as at inducing the capacity for mucosal recall responses.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
26 articles.
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