Affiliation:
1. Department of Pathobiological Sciences, School of Veterinary Medicine, Madison, Wisconsin 53706
Abstract
ABSTRACT
In this study we found that serum inhibitory activity against
Blastomyces dermatitidis
was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit
B
.
dermatitidis
growth in vivo; however, the addition of albumin restored inhibitory activity. Inhibitory activity does not require albumin domain III and appears to involve binding of a low-molecular-weight yeast-derived growth factor.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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