Albumin Neutralizes Hydrophobic Toxins and Modulates Candida albicans Pathogenicity

Author:

Austermeier Sophie1ORCID,Pekmezović Marina1ORCID,Porschitz Pauline2,Lee Sejeong3ORCID,Kichik Nessim3,Moyes David L.3ORCID,Ho Jemima3ORCID,Kotowicz Natalia K.3ORCID,Naglik Julian R.3ORCID,Hube Bernhard14ORCID,Gresnigt Mark S.2ORCID

Affiliation:

1. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

2. Junior Research Group Adaptive Pathogenicity Strategies, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Jena, Germany

3. Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral and Craniofacial Sciences, King’s College London, London, United Kingdom

4. Institute for Microbiology, Friedrich Schiller University of Jena, Jena, Germany

Abstract

Albumin is the most abundant serum protein in humans. During inflammation, serum albumin levels decrease drastically, and low albumin levels are associated with poor patient outcome.

Funder

Deutsche Forschungsgemeinschaft

Alexander von Humboldt-Stiftung

European Society of Clinical Microbiology and Infectious Diseases

European Union Horizon 2020 research and innovation program

Wellcome Trust

HHS | National Institutes of Health

NIH Research at Guys and St. Thomas's NHS Foundation Trust

King's College London

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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