Concurrent Upregulation of Urokinase Plasminogen Activator Receptor and CD11b during Tuberculosis and Experimental Endotoxemia

Author:

Juffermans Nicole P.12,Dekkers Pascale E. P.1,Verbon Annelies12,Speelman Peter2,van Deventer Sander J. H.1,van der Poll Tom12

Affiliation:

1. Laboratory of Experimental Internal Medicine1 and

2. Department of Internal Medicine,2 Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

ABSTRACT Patients with tuberculosis had higher expression of monocyte urokinase receptor (uPAR) and CD11b than controls. In vitro, lipoarabinomannan and lipopolysaccharide (LPS) from Escherichia coli shared the ability to enhance uPAR and CD11b expression on monocytes and granulocytes. In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference16 articles.

1. Endotoxin stimulates expression of the murine urokinase receptor gene in vivo;Almus-Jacobs F.;Am. J. Pathol.,1995

2. uPA, uPAR, PAI-1: key intersection of proteolytic, adhesive and chemotactic highways?;Blasi F.;Immunol. Today,1997

3. Upregulation of monocyte urokinase plasminogen activator receptor during human endotoxemia;Dekkers P. E. P.;Infect. Immun.,2000

4. Function of the urokinase receptor (CD87) in neutrophil chemotaxis;Gyetko M. R.;J. Leukoc. Biol.,1995

5. The urokinase receptor is required for human monocyte chemotaxis in vitro;Gyetko M. R.;J. Clin. Investig.,1994

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