Differential Effects of Prostaglandin D 2 Signaling on Macrophages and Microglia in Murine Coronavirus Encephalomyelitis-Reference-Cited by-同舟云学术

Differential Effects of Prostaglandin D 2 Signaling on Macrophages and Microglia in Murine Coronavirus Encephalomyelitis

Published:2021-10-26 Issue:5 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Verma Abhishek Kumar¹,Zheng Jian¹,Mack Matthias²,Ginhoux Florent³⁴⁵,Perlman Stanley¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA

2. Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany

3. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

4. Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore

5. Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore

Abstract

Current understanding about the roles of microglia versus macrophages in viral encephalitis is limited. We previously showed that the signaling of a single prostaglandin, PGD 2 , through its DP1 receptor on myeloid cells is critical for optimal immune responses in infected mice.

Funder

HHS | U.S. Public Health Service

National Multiple Sclerosis Society

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01969-21

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