Pneumolysin Potentiates Production of Prostaglandin E 2 and Leukotriene B 4 by Human Neutrophils-Reference-Cited by-同舟云学术

Pneumolysin Potentiates Production of Prostaglandin E 2 and Leukotriene B 4 by Human Neutrophils

Published:2001-05 Issue:5 Volume:69 Page:3494-3496
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cockeran Riana¹,Steel Helen C.¹,Mitchell Timothy J.²,Feldman Charles³,Anderson Ronald¹

Affiliation:

1. Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Institute for Pathology, University of Pretoria, Pretoria,1and

2. Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland2

3. Division of Pulmonology, Johannesburg Hospital and University of the Witwatersrand, Johannesburg,3 South Africa, and

Abstract

ABSTRACT Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E 2 and leukotriene B 4 by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.5.3494-3496.2001

Reference10 articles.

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3. Asthma and leukotrienes: antileukotrienes as novel antiasthmatic drugs;Cleasson H. E.;J. Int. Med.,1999

4. Proinflammatory interactions of pneumolysin with human neutrophils;Cockeran R.;J. Infect. Dis.,2001

5. Immunomodulation by neutrophil myeloperoxidase and hydrogen peroxide: differential susceptibility of human lymphocyte functions;El-Hag A.;J. Immunol.,1986

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