Genetic and Functional Variability of AmpC-Type β-Lactamases from Acinetobacter baumannii-Reference-Cited by-同舟云学术

Genetic and Functional Variability of AmpC-Type β-Lactamases from Acinetobacter baumannii

Published:2010-11 Issue:11 Volume:54 Page:4930-4933
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rodríguez-Martínez José-Manuel¹,Poirel Laurent¹,Nordmann Patrice¹

Affiliation:

1. Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine, and Université Paris-Sud, Hôpital de Bicêtre, 94275 K.-Bicêtre, France

Abstract

ABSTRACT The incidence of naturally occurring AmpC β-lactamases with extended activities toward several cephalosporins was evaluated among 17 ceftazidime (CAZ)-resistant Acinetobacter baumannii isolates. Five AmpC β-lactamases (named ADC β-lactamases) were identified, among which those possessing the Val208Ala (inside the omega-loop) or Asn283Ser (helix H-10) substitution conferred higher levels of resistance (4- to 64-fold higher) to CAZ and to cefotaxime in Escherichia coli . This study demonstrates that peculiar AmpCs playing a role in resistance to broad-spectrum cephalosporins in A. baumannii may be identified.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00427-10

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