Comparison of In Vitro Antimicrobial Activity of Cefamandole and Cefazolin with Cephalothin Against over 8,000 Clinical Bacterial Isolates

Author:

Jones Ronald N.1,Fuchs Peter C.

Affiliation:

1. Department of Pathology, Kaiser Foundation Hospital Laboratories, Portland, Oregon 97217,

Abstract

Antimicrobial susceptibility to cefamandole versus cephalothin and cefazolin versus cephalothin was compared by the broth microdilution method against 3,000 and 5,895 clinical bacterial isolates, respectively. Cefamandole and, to a lesser degree, cefazolin showed greater activity than cephalothin against Enterobacteriaceae , but the three drugs were comparable against gram-positive cocci.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference12 articles.

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2. In vitro studies with cefazolin;Motley M.;Antimicrob. Agents Chemother.,1974

3. Cefamondole, a cephalosporin antibiotic with an unusually wide spectrum of activity;Neu H. C.;Antimicrob. Agents Chemother.,1974

4. Nishida M. T. Matsubara T. Marakawa Y. Mine Y. Yokota S. Kuwahara and S. Goto. 1970. In vitro and in vivo evaluation of cefazolin a new cephalosporin C derivative p. 236-243. Antimicrob. Agents Chemother. 1969.

5. Comparison of cefazolin, a new cephaolsporin antibiotic, with cephalothins;Phair J. P.;Antimicrob. Agents Chemother.,1972

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