In Vitro Studies with Cefazolin

Author:

Motley Milwood12,Shadomy Smith12

Affiliation:

1. Department of Microbiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298

2. Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298

Abstract

Susceptibilities of 259 isolates of pathogenic bacteria to cefazolin were measured by broth and agar dilution procedures. Beta-hemolytic streptococci were inhibited by 0.25 μg/ml, whereas Staphylococcus aureus and alphahemolytic streptococci were inhibited by 2.0 μg/ml. Enterococci were resistant to less than 32 μg/ml. Wide variation was seen with gram-negative species. Most isolates of Klebsiella species and Proteus mirabilis were inhibited by 4.0 or 8.0 μg/ml. Escherichia coli were less susceptible, and most isolates of Pseudomonas aeruginosa, Serratia species, and Enterobacter species were resistant to 128 μg/ml.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference12 articles.

1. Anderson T. G. 1970. Testing of susceptibility to antimicriobial agents and assay of antimicrobial agents in body fluids p. 305-307. In J. E. Blair E. H. Lennette and J. P. Truant (ed.) Manual of clinical microbiology. American Society for Microbiology Bethesda Md.

2. Bactericidal activity and pharmacology of cefazolin;Bergeron M. G.;Antimicrob. Ag. Chemother.,1973

3. Cefazolin therapy of urinary tract infections;Cox C. E.;J. Infect. Dis.,1973

4. Ericsson H. M. and J. C. Sherris. 1971. Antibiotic sensitivity testing. Report of an international col

5. VOL 6 1974

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