Emergence of Carbapenem-Resistant Providencia rettgeri and Providencia stuartii Producing IMP-Type Metallo-β-Lactamase in Japan-Reference-Cited by-同舟云学术

Emergence of Carbapenem-Resistant Providencia rettgeri and Providencia stuartii Producing IMP-Type Metallo-β-Lactamase in Japan

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Iwata Shu¹,Tada Tatsuya¹,Hishinuma Tomomi¹,Tohya Mari¹,Oshiro Satoshi¹,Kuwahara-Arai Kyoko¹,Ogawa Miho²,Shimojima Masahiro²,Kirikae Teruo¹^ORCID

Affiliation:

1. Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan

2. BML, Inc., Kawagoe, Saitama, Japan

Abstract

Four Providencia rettgeri isolates and one Providencia stuartii isolate were obtained from urine samples of five patients in 2018 in Japan. All of the isolates were resistant to imipenem and meropenem, and three were highly resistant to both carbapenems, with MICs of 512 μg/ml. The three highly carbapenem-resistant isolates harbored bla IMP-70 , encoding a variant of IMP-1 metallo-β-lactamase with two amino acid substitutions (Val67Phe and Phe87Val), and the other two harbored bla IMP-1 and bla IMP-11 , respectively.

Funder

Training Program for Medical Students

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00382-20

Reference44 articles.

1. Natural antibiotic susceptibility of Providencia stuartii, P. rettgeri, P. alcalifaciens and P. rustigianii strains