Prevalence of a Cefazolin Inoculum Effect Associated with blaZ Gene Types among Methicillin-Susceptible Staphylococcus aureus Isolates from Four Major Medical Centers in Chicago-Reference-Cited by-同舟云学术

Prevalence of a Cefazolin Inoculum Effect Associated with blaZ Gene Types among Methicillin-Susceptible Staphylococcus aureus Isolates from Four Major Medical Centers in Chicago

Published:2018-08 Issue:8 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Sheila K.¹²,Gilchrist Annette³,Loukitcheva Anastasia¹,Plotkin Balbina J.⁴,Sigar Ira M.⁴,Gross Alan E.⁵,O'Donnell J. Nicholas¹⁶,Pettit Natasha⁷,Buros Amy⁸,O'Driscoll Tristan¹²,Rhodes Nathaniel J.¹⁶^ORCID,Bethel Cindy⁹,Segreti John¹⁰,Charnot-Katsikas Angella⁹,Singh Kamaljit¹⁰,Scheetz Marc H.¹⁶^ORCID

Affiliation:

1. Department of Pharmacy Practice, Midwestern University, Downers Grove, Illinois, USA

2. Department of Pharmacy, Rush University Medical Center, Chicago, Illinois, USA

3. Department of Pharmaceutical Sciences, Midwestern University, Downers Grove, Illinois, USA

4. Department of Microbiology and Immunology, Midwestern University, Downers Grove, Illinois, USA

5. Department of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, USA

6. Department of Pharmacy, Northwestern Memorial Hospital, Chicago, Illinois, USA

7. Department of Pharmacy, University of Chicago Medical Center, Chicago, Illinois, USA

8. Midwestern University, Glendale, Arizona, USA

9. Department of Pathology, University of Chicago Medical Center, Chicago, Illinois, USA

10. Division of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA

Abstract

The efficacy of cefazolin with high-inoculum methicillin-susceptible Staphylococcus aureus (MSSA) infections remains in question due to therapeutic failure inferred as being due to an inoculum effect (InE). This study investigated the local prevalence of a cefazolin InE (CInE) and its association with staphylococcal blaZ gene types among MSSA isolates in the Chicago area.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00382-18

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