Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women-Reference-Cited by-同舟云学术

Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hughes Emma¹,Imperial Marjorie¹,Wallender Erika²^ORCID,Kajubi Richard³,Huang Liusheng²,Jagannathan Prasanna⁴^ORCID,Zhang Nan¹,Kakuru Abel³,Natureeba Paul³,Mwima Moses W.³,Muhindo Mary³,Mwebaza Norah⁵,Clark Tamara D.⁶,Opira Bishop³,Nakalembe Miriam³,Havlir Diane⁶,Kamya Moses³⁷,Rosenthal Philip J.⁶^ORCID,Dorsey Grant⁶,Aweeka Francesca²,Savic Radojka M.¹^ORCID

Affiliation:

1. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA

2. Department of Clinical Pharmacy, University of California, San Francisco, California, USA

3. Infectious Disease Research Collaboration, Kampala, Uganda

4. Department of Medicine, Stanford University, California, USA

5. Department of Pharmacology & Therapeutics, Makerere University College of Health Sciences, Kampala, Uganda

6. Department of Medicine, University of California San Francisco, San Francisco, California, USA

7. Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda

Abstract

Dihydroartemisinin-piperaquine (DHA-PQ) provides highly effective therapy and chemoprevention for malaria in pregnant African women. PQ concentrations of >10.3 ng/ml have been associated with reduced maternal parasitemia, placental malaria, and improved birth outcomes. We characterized the population pharmacokinetics (PK) of PQ in a post hoc analysis of human immunodeficiency virus (HIV)-infected and -uninfected pregnant women receiving DHA-PQ as chemoprevention every 4 or 8 weeks.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01013-20

Reference61 articles.

1. Quantifying the Number of Pregnancies at Risk of Malaria in 2007: A Demographic Study

2. World Health Organization. 2019. World Malaria Report 2019. World Health Organization Geneva Switzerland. https://www.who.int/publications/i/item/9789241565721.

3. Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study

4. Contribution of Noncommunicable Diseases to Medical Admissions of Elderly Adults in Africa: A Prospective, Cross-Sectional Study in Nigeria, Sudan, and Tanzania

5. Mediation of the effect of malaria in pregnancy on stillbirth and neonatal death in an area of low transmission: observational data analysis

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