Second-Generation Live-Attenuated Candid#1 Vaccine Virus Resists Reversion and Protects against Lethal Junín Virus Infection in Guinea Pigs-Reference-Cited by-同舟云学术

Second-Generation Live-Attenuated Candid#1 Vaccine Virus Resists Reversion and Protects against Lethal Junín Virus Infection in Guinea Pigs

Published:2021-06-24 Issue:14 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Gowen Brian B.¹^ORCID,Hickerson Brady T.¹^ORCID,York Joanne²,Westover Jonna B.¹,Sefing Eric J.¹,Bailey Kevin W.¹,Wandersee Luci¹,Nunberg Jack H.²^ORCID

Affiliation:

1. Department of Animal, Dairy and Veterinary Sciences, Utah State University, Logan, Utah, USA

2. Montana Biotechnology Center, University of Montana, Missoula, Montana, USA

Abstract

Our most successful vaccines comprise weakened strains of virus that initiate a limited and benign infection in immunized persons. The live-attenuated Candid#1 strain of Junín virus (JUNV) was developed to protect field workers in Argentina from rodent-borne hemorrhagic fever but is not licensed in the United States, in part due to the likelihood of genetic reversion to virulence.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00397-21

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