Affiliation:
1. Department of Microbiology, Osaka University Medical School, Osaka 565-0871, Japan
Abstract
ABSTRACT
The human herpesvirus 6 (HHV-6) variant A U100 gene encodes the third component of the glycoprotein H (gH)-glycoprotein L (gL)-containing complex. Glycosidase digestion analysis showed that the U100 gene products are glycoproteins consisting of an 80-kDa protein with complex N-linked oligosaccharides and a 74-kDa protein with immature, high-mannose N-linked oligosaccharides. Based on these characteristics, we designated the U100 gene products glycoprotein Q (gQ). Only the 80-kDa form of gQ was coimmunoprecipitated with an anti-gH antibody, suggesting that the 80-kDa protein associates with the gH-gL complex in HHV-6-infected cells. Furthermore, the complex was detected in purified virions, suggesting that it may play an important role in viral entry.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference44 articles.
1. Ablashi, D. V., N. Balachandran, S. F. Josephs, C. L. Hung, G. R. Krueger, B. Kramarsky, S. Z. Salahuddin, and R. C. Gallo. 1991. Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184 : 545-552.
2. Chandran, B., S. Tirawatnapong, B. Pfeiffer, and D. V. Ablashi. 1992. Antigenic relationships among human herpesvirus-6 isolates. J. Med. Virol. 37 : 247-254.
3. Dhepakson, P., Y. Mori, Y. B. Jiang, H. L. Huang, P. Akkapaiboon, T. Okuno, and K. Yamanishi. 2002. Human herpesvirus-6 rep/U94 gene product has single-stranded DNA-binding activity. J. Gen. Virol. 83 : 847-854.
4. Human Herpesvirus 6B Genome Sequence: Coding Content and Comparison with Human Herpesvirus 6A
5. Downing, R. G., N. Sewankambo, D. Serwadda, R. Honess, D. Crawford, R. Jarrett, and B. E. Griffin. 1987. Isolation of human lymphotropic herpesviruses from Uganda. Lancet ii : 390.
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