A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus-Reference-Cited by-同舟云学术

A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ganapathy Uday S.¹,del Río Rubén González²,Cacho-Izquierdo Mónica²,Ortega Fátima²,Lelièvre Joël²,Barros-Aguirre David²^ORCID,Aragaw Wassihun Wedajo¹,Zimmerman Matthew D.¹,Lindman Marissa¹,Dartois Véronique¹³^ORCID,Gengenbacher Martin¹³^ORCID,Dick Thomas¹³⁴^ORCID

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Global Health Pharma Unit, GlaxoSmithKline, Tres Cantos, Madrid, Spain

3. Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA

4. Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA

Abstract

Fluoroquinolones—the only clinically used DNA gyrase inhibitors—are effective against tuberculosis (TB) but are in limited clinical use for nontuberculous mycobacteria (NTM) lung infections due to intrinsic drug resistance. We sought to test alternative DNA gyrase inhibitors for anti-NTM activity. Mycobacterium tuberculosis Gyrase Inhibitors (MGIs), a subclass of Novel Bacterial Topoisomerase Inhibitors (NBTIs), were recently shown to be active against the tubercle bacillus.

Funder

HHS | National Institutes of Health

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01514-21

Reference63 articles.

1. The Taxonomy of the Genus Mycobacterium

3. Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus