Anti-Human Immunodeficiency Virus Type 1 Activities of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins-Reference-Cited by-同舟云学术

Anti-Human Immunodeficiency Virus Type 1 Activities of Antimicrobial Peptides Derived from Human and Bovine Cathelicidins

Published:2008-09 Issue:9 Volume:52 Page:3438-3440
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wang Guangshun¹,Watson Karen M.²,Buckheit Robert W.²

Affiliation:

1. The Structure-Fun Laboratory, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, Nebraska 68198

2. ImQuest BioSciences, Inc., 7340 Executive Way, Suite R, Frederick, Maryland 21704

Abstract

ABSTRACT From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00452-08

Reference37 articles.

1. Barlow, D. J., and J. M. Thornton. 1988. Helix geometry in proteins. J. Mol. Biol.201:601-619.

2. Bergman, P., L. Walter-Jallow, K. Broliden, B. Agerberth, and J. Soderlund. 2007. The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr. HIV Res.5:410-415.

3. Boman, H. G. 2003. Antibacterial peptides: basic facts and emerging concepts. J. Intern. Med.254:197-215.

4. Braff, M. H., M. A. Hawkins, A. Di Nardo, B. Lopez-Garcia, M. D. Howell, C. Wong, K. Lin, J. E. Streib, R. Dorschner, D. Y. Leung, and R. L. Gallo. 2005. Structure-function relationships among human cathelicidin peptides: dissociation of antimicrobial properties from host immunostimulatory activities. J. Immunol.174:4271-4278.

5. Buckheit, R. W., Jr. 2001. Non-nucleoside reverse transcriptase inhibitors: perspectives on novel therapeutic compounds and strategies for the treatment of HIV infection. Expert Opin. Investig. Drugs10:1423-1442.

Cited by 105 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enzyme-responsive oncolytic polypeptide for tumor therapy;Acta Biomaterialia;2024-06

2. The role of cathelicidins in neutrophil biology;Journal of Leukocyte Biology;2024-05-17

3. Antiviral effect of peptoids on hepatitis B virus infection in cell culture;Antiviral Research;2024-03

4. Inflammation-suppressing cornea-in-a-syringe with anti-viral GF19 peptide promotes regeneration in HSV-1 infected rabbit corneas;npj Regenerative Medicine;2024-03-01

5. Modified host defence peptide GF19 slows TNT-mediated spread of corneal herpes simplex virus serotype I infection;Scientific Reports;2024-02-19