The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli-Reference-Cited by-同舟云学术

The Arginine Deiminase Operon Is Responsible for a Fitness Trade-Off in Extended-Spectrum-β-Lactamase-Producing Strains of Escherichia coli

Published:2019-08 Issue:8 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Billard-Pomares Typhaine¹²,Clermont Olivier¹,Castellanos Miguel¹,Magdoud Fatma²,Royer Guilhem¹³,Condamine Bénédicte¹,Fouteau Stéphanie⁴,Barbe Valérie⁴,Roche David³,Cruveiller Stéphane³,Médigue Claudine⁴,Pognard Dominique⁵,Glodt Jeremy¹⁵,Dion Sara¹,Rigal Odile⁶,Picard Bertrand¹²,Denamur Erick¹⁷,Branger Catherine¹

Affiliation:

1. IAME, UMR 1137, INSERM, Université Paris Diderot, Université Paris 13, Sorbonne Paris Cité, Paris, France

2. APHP, Hôpital Avicenne, Service de Microbiologie clinique, Bobigny, France

3. UMR 8030, CNRS, Institut de Génomique-Genoscope, Laboratoire d’Analyses Bioinformatiques pour la Génomique et le Métabolisme, Université Évry-Val-d'Essonne, CEA, Évry, France

4. Génomique Métabolique, Genoscope, Institut de biologie François Jacob, CEA, CNRS, Université Evry, Université Paris-Saclay, Evry, France

5. APHP, Hôpital Louis Mourier, Service de Microbiologie, Colombes, France

6. Service de Biochimie-Hormonologie, Hôpital Robert Debré, Paris, France

7. APHP, Laboratoire de Génétique Moléculaire, Hôpital Bichat, Paris, France

Abstract

We previously identified an operon involved in an arginine deiminase (ADI) pathway ( arc operon) on a CTX-M-producing plasmid from an O102-ST405 strain of Escherichia coli . As the ADI pathway was shown to be involved in the virulence of various Gram-positive bacteria, we tested whether the ADI pathway could be involved in the epidemiological success of extended-spectrum-β-lactamase (ESBL)-producing E. coli strains.

Funder

Fondation pour la Recherche Médicale

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00635-19

Reference78 articles.

1. Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat

2. Animal and human pathogenic Escherichia coli strains share common genetic backgrounds