High Incidence of Escherichia coli Strains Coharboring mcr-1 and bla NDM from Chickens-Reference-Cited by-同舟云学术

High Incidence of Escherichia coli Strains Coharboring mcr-1 and bla NDM from Chickens

Published:2017-03 Issue:3 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Liu Bao-Tao¹²,Song Feng-Jing³,Zou Ming¹,Zhang Qi-Di¹,Shan Hu¹²

Affiliation:

1. College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao, China

2. Engineering Technology Research Center of Veterinary Medicine and Diagnostic Reagents of Shandong Province, Qingdao Agricultural University, Qingdao, China

3. Qingdao Academy of Agricultural Sciences, Qingdao, China

Abstract

ABSTRACT This study investigated the characteristics of Escherichia coli isolates carrying mcr-1-bla NDM from a chicken farm in China. Of the 78 E. coli isolates, 21 clonally unrelated isolates carried mcr-1-bla NDM . Diverse IncI2 plasmids disseminated mcr-1 , while the dissemination of bla NDM was mediated by diverse IncB/O plasmids. More striking was the colocalization of resistance genes mcr-1 and bla NDM-4 in an IncHI2/ST3 plasmid, which might pose a great challenge for public health.

Funder

Natural Science Foundation of Shandong Province of China

Scientific and Technological Projects of Qingdao

Advanced Talents Foundation of Qingdao Agricultural University

Priority Academic Talent Team Cultivation Program of Shandong Colleges and Universities

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02347-16