Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model-Reference-Cited by-同舟云学术

Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Dhakal Santosh¹^ORCID,Ruiz-Bedoya Camilo A.²,Zhou Ruifeng¹,Creisher Patrick S.¹,Villano Jason S.³,Littlefield Kirsten¹,Ruelas Castillo Jennie⁴,Marinho Paula¹,Jedlicka Anne E.¹,Ordonez Alvaro A.²,Bahr Melissa²,Majewska Natalia⁵,Betenbaugh Michael J.⁵,Flavahan Kelly²,Mueller Alice R. L.¹,Looney Monika M.⁴,Quijada Darla⁴,Mota Filipa²,Beck Sarah E.³,Brockhurst Jacqueline³,Braxton Alicia M.³,Castell Natalie³,Stover Mitchel³,D’Alessio Franco R.⁴,Metcalf Pate Kelly A.³^ORCID,Karakousis Petros C.⁴,Mankowski Joseph L.³,Pekosz Andrew¹³^ORCID,Jain Sanjay K.²^ORCID,Klein Sabra L.¹^ORCID

Affiliation:

1. W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

2. Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

3. Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA

4. Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA

5. Advanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA

Abstract

Men experience more severe outcomes from coronavirus disease 2019 (COVID-19) than women. Golden Syrian hamsters were used to explore sex differences in the pathogenesis of a human clinical isolate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute on Aging

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00974-21

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