Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii-Reference-Cited by-同舟云学术

Characterization of pABVA01, a Plasmid Encoding the OXA-24 Carbapenemase from Italian Isolates of Acinetobacter baumannii

Published:2009-08 Issue:8 Volume:53 Page:3528-3533
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

D'Andrea Marco Maria¹,Giani Tommaso¹,D'Arezzo Silvia²,Capone Alessandro²,Petrosillo Nicola²,Visca Paolo²³,Luzzaro Francesco⁴,Rossolini Gian Maria¹⁵

Affiliation:

1. Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena

2. Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, I-00149 Roma

3. Dipartimento di Biologia, Università Roma Tre, I-00146 Roma

4. Laboratorio di Microbiologia Ospedale di Circolo, Università dell'Insubria, I-21100 Varese, Italy

5. Unità Operativa di Microbiologia e Virologia, Dipartimento dei Servizi, Azienda Ospedaliera-Universitaria Senese, I-53100 Siena

Abstract

ABSTRACT Two epidemiologically unrelated carbapenem-resistant Acinetobacter baumannii isolates were investigated as representatives of the first Italian isolates producing the OXA-24 carbapenemase. Both isolates were of European clonal lineage II and carried an identical OXA-24-encoding plasmid, named pABVA01. Comparative analysis revealed that in pABVA01, bla OXA-24 was part of a DNA module flanked by conserved inverted repeats homologous to XerC/XerD binding sites, which in other Acinetobacter plasmids flank different DNA modules, suggesting mobilization by a novel site-specific recombination mechanism.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00178-09

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