Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase Inhibitors-Reference-Cited by-同舟云学术

Diversity and Proliferation of Metallo-β-Lactamases: a Clarion Call for Clinically Effective Metallo-β-Lactamase Inhibitors

Published:2018-09-15 Issue:18 Volume:84 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Somboro Anou M.¹²,Osei Sekyere John³^ORCID,Amoako Daniel G.¹²,Essack Sabiha Y.¹,Bester Linda A.²

Affiliation:

1. Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

2. Biomedical Resource Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

3. Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa

Abstract

The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-negative bacteria is a serious concern to public health. MBLs are compromising the therapeutic efficacies of β-lactams, particularly carbapenems, which are last-resort antibiotics indicated for various multidrug-resistant bacterial infections.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00698-18

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