Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration-Reference-Cited by-同舟云学术

Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration

Published:2024-02-22 Issue:5 Volume:67 Page:3400-3418
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Dong Shuzhi¹^ORCID,Zhao Zhiqiang¹^ORCID,Tang Haiqun¹,Li Guoqing¹,Pan Jianping¹,Gu Xin¹,Jiang Jinlong¹^ORCID,Xiao Li²,Scapin Giovanna²,Hunter David N.¹,Yang Dexi¹,Huang Yuhua¹^ORCID,Bennett Frank¹,Yang Shu-Wei¹,Mandal Mihirbaran¹^ORCID,Tang Haifeng¹,Su Jing¹,Tudge Clare¹,deJesus Reynalda Keh¹,Ding Fa-Xiang¹,Lombardo Matthew¹,Hicks Jacqueline D.¹,Fischmann Thierry²,Mirza Asra³,Dayananth Priya⁴,Painter Ronald E.⁴,Villafania Artjohn⁴,Garlisi Charles G.⁴,Zhang Rumin⁴,Mayhood Todd W.⁴,Si Qian⁴,Li Nianyu⁵,Amin Rupesh P.⁵,Bhatt Bhavana⁵,Chen Feifei⁵,Regan Christopher P.⁵,Regan Hillary⁵,Lin Xinjie⁶,Wu Jin⁶,Leithead Andrew⁷,Pollack Scott R.⁸^ORCID,Scott Jack D.¹^ORCID,Nargund Ravi P.¹,Therien Alex G.⁹,Black Todd³,Young Katherine³,Pasternak Alexander¹

Affiliation:

1. Discovery Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

2. Computational and Structural Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

3. Antibacterial/Antifungal, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

4. Quantitative Biosciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

5. Nonclinical Drug Safety, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

6. Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc., Rahway, New Jersey 07065, United States

7. Discovery Pharmaceutical Sciences, Merck & Co., Inc., West Point, Pennsylvania 19486, United States

8. Discovery Process Chemistry, Merck & Co., Inc., Rahway, New Jersey 07065, United States

9. Exploratory Science Center, Merck & Co., Inc., Cambridge, Massachusetts 02139, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01614

Reference43 articles.

1. Updated Functional Classification of β-Lactamases

2. The latest advances in β-lactam/β-lactamase inhibitor combinations for the treatment of Gram-negative bacterial infections

3. The β-Lactams Strike Back: Ceftazidime-Avibactam

4. Imipenem–Relebactam and Meropenem–Vaborbactam: Two Novel Carbapenem-β-Lactamase Inhibitor Combinations

5. Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae