Effects of Serum on In Vitro Susceptibility Testing of Echinocandins-Reference-Cited by-同舟云学术

Effects of Serum on In Vitro Susceptibility Testing of Echinocandins

Published:2007-11 Issue:11 Volume:51 Page:4214-4216
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Odabasi Zekaver¹,Paetznick Victor²,Rex John H.²,Ostrosky-Zeichner Luis²

Affiliation:

1. Marmara University Hospital, Istanbul, Turkey

2. University of Texas Health Science Center, Houston, Texas

Abstract

ABSTRACT The effects of protein binding on the activities of caspofungin, anidulafungin, and micafungin were evaluated against Candida and Aspergillus species. Adding human serum sharply increased the MICs of micafungin and anidulafungin and modestly affected the MIC of caspofungin. The increase in MICs does not appear consistent with the rate of protein binding for the three compounds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01589-06

Reference18 articles.

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4. In Vitro Activity of Micafungin (FK-463) against Candida spp.: Microdilution, Time-Kill, and Postantifungal-Effect Studies

5. Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872)

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