Human Tissue Distribution of Anidulafungin and Micafungin-Reference-Cited by-同舟云学术

Human Tissue Distribution of Anidulafungin and Micafungin

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Marx Jana¹,Welte René¹,Gasperetti Tiziana¹,Moser Patrizia²,Joannidis Michael³,Bellmann Romuald¹^ORCID

Affiliation:

1. Clinical Pharmacokinetics Unit, Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria

2. Department of Pathology, Medical University of Innsbruck, Innsbruck, Austria

3. Division of Intensive Care and Emergency Medicine, Department of Internal Medicine I, Medical University of Innsbruck, Innsbruck, Austria

Abstract

Concentrations of anidulafungin and micafungin were determined in eight different tissues obtained during autopsy of four deceased individuals who had been treated with anidulafungin and of seven who had received micafungin. The largest amounts were recovered from liver, with anidulafungin concentrations of 11.01 to 66.50 μg/g and micafungin levels of 0.36 to 5.53 μg/g (0.65 μg/g 30 days after the last administration).

Funder

Austrian Science Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00169-21

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