Characterization of the Secreted MPT53 Antigen of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Characterization of the Secreted MPT53 Antigen of Mycobacterium tuberculosis

Published:2001-09 Issue:9 Volume:69 Page:5936-5939
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Johnson Sadie¹,Brusasca PierNatale¹,Lyashchenko Konstantin¹,Spencer John S.²,Wiker Harald G.³,Bifani Pablo¹,Shashkina Elena¹,Kreiswirth Barry¹,Harboe Morten⁴,Schluger Neil⁵,Gomez Manuel¹,Gennaro Maria Laura¹

Affiliation:

1. Public Health Research Institute, New York, New York, 100161;

2. Colorado State University, Fort Collins, Colorado 805232;

3. National Institute of Public Health, N-0403 Oslo,3 and

4. Institute of Immunology, The National Hospital, N-0027 Oslo,4 Norway; and

5. Columbia University College of Physicians and Surgeons, New York, New York, 100325

Abstract

ABSTRACT MPT53 is a secreted protein of Mycobacterium tuberculosis . Southern transfer and hybridization showed mpt53 to be conserved in the M. tuberculosis complex and to have homology with DNA from Mycobacterium avium and other nontuberculous mycobacteria. However, anti-MPT53 polyclonal antibodies detected no antigen in the culture filtrates of M. avium and other nontuberculous mycobacteria. MPT53 of M. tuberculosis induced strong, tuberculosis-specific antibody responses in guinea pigs but induced no delayed-type hypersensitivity. Involvement in immune responses during human tuberculosis was very modest.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.9.5936-5939.2001

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