MTSA-10, the Product of the Rv3874 Gene of Mycobacterium tuberculosis , Elicits Tuberculosis-Specific, Delayed-Type Hypersensitivity in Guinea Pigs-Reference-Cited by-同舟云学术

MTSA-10, the Product of the Rv3874 Gene of Mycobacterium tuberculosis , Elicits Tuberculosis-Specific, Delayed-Type Hypersensitivity in Guinea Pigs

Published:2000-02 Issue:2 Volume:68 Page:990-993
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Colangeli Roberto¹,Spencer John S.²,Bifani Pablo¹,Williams Alan³,Lyashchenko Konstantin¹,Keen Marc A.²,Hill Preston J.²,Belisle John²,Gennaro Maria Laura¹

Affiliation:

1. Public Health Research Institute, New York, New York 100161;

2. Colorado State University, Fort Collins, Colorado 805232; and

3. Amersham-Pharmacia Biotech, Piscataway, New Jersey 08855-13273

Abstract

ABSTRACT In a search for new skin test reagents specific for tuberculosis, we found that the antigen encoded by gene Rv3874 of Mycobacterium tuberculosis elicited delayed-type hypersensitivity in M. tuberculosis -infected guinea pigs but not in control animals immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium avium . The antigen, which was named MTSA-10 (for M. tuberculosis -specific antigen 10), is a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test of latent M. tuberculosis infection from vaccination with BCG or from sensitization with environmental, nontuberculous mycobacteria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.2.990-993.2000

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