Selection of Bifidobacteria Based on Adhesion and Anti-Inflammatory Capacity In Vitro for Amelioration of Murine Colitis

Author:

Preising Julia1,Philippe David2,Gleinser Marita1,Wei Hua1,Blum Stephanie2,Eikmanns Bernhard J.1,Niess Jan-Hendrik3,Riedel Christian U.1

Affiliation:

1. Institute of Microbiology and Biotechnology, University of Ulm, 89068 Ulm, Germany

2. Immunology Group, Nutrition and Health Department, Nestlé Research Center, P.O. Box 44, CH-1026 Lausanne, Switzerland

3. Department of Internal Medicine I, University of Ulm, 89068 Ulm, Germany

Abstract

ABSTRACT Adhesion and anti-inflammatory properties of eight strains of bifidobacteria were tested using the intestinal epithelial cell lines Caco-2, T84, and HT29. Two strains were selected for further assessment of their anti-inflammatory capacity in two murine models of colitis. In vivo results confirmed the high anti-inflammatory capacity of a Bifidobacterium bifidum strain.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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