Boosting Vaccine for Tuberculosis-Reference-Cited by-同舟云学术

Boosting Vaccine for Tuberculosis

Published:2001-04 Issue:4 Volume:69 Page:2714-2717
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Brooks Jason V.¹²,Frank Anthony A.¹³,Keen Marc A.¹²,Bellisle John T.¹²,Orme Ian M.¹²

Affiliation:

1. Mycobacteria Research Laboratories1 and

2. Departments of Microbiology2 and

3. Pathology,3 Colorado State University, Fort Collins, Colorado 80523

Abstract

ABSTRACT An effective new vaccine for the control of tuberculosis is badly needed. While current research attempts to improve vaccination are concentrating on new prophylactic or immunotherapeutic vaccines, virtually no emphasis has been placed on boosting individuals already inoculated with Mycobacterium bovis BCG. It is shown here that mice vaccinated with BCG gradually lose their capacity to resist an aerosol challenge infection as they age. However, if these mice are inoculated with the 30-kDa mycolyl transferase A protein in midlife, after challenge when aged they express levels of protection in the lungs comparable to those of young mice, associated with minimal pathological damage.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.4.2714-2717.2001

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4. Tuberculosis: commentary on a reemergent killer;Bloom B. R.;Science,1992

5. Efficacy of BCG Vaccine in the Prevention of Tuberculosis

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