Role of the Major Antigen of Mycobacterium tuberculosis in Cell Wall Biogenesis-Reference-Cited by-同舟云学术

Role of the Major Antigen of Mycobacterium tuberculosis in Cell Wall Biogenesis

Published:1997-05-30 Issue:5317 Volume:276 Page:1420-1422
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Belisle John T.¹²,Vissa Varalakshmi D.¹²,Sievert Todd¹²,Takayama Kuni¹²,Brennan Patrick J.¹²,Besra Gurdyal S.¹²

Affiliation:

1. J. T. Belisle, V. D. Vissa, P. J. Brennan, G. S. Besra, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA.

2. T. Sievert and K. Takayama, Mycobacteriology Research Laboratory, William S. Middleton Memorial Veterans Hospital, University of Wisconsin, Madison, WI 53705, USA.

Abstract

The dominant exported proteins and protective antigens of Mycobacterium tuberculosis are a triad of related gene products called the antigen 85 (Ag85) complex. Each has also been implicated in disease pathogenesis through its fibronectin-binding capacities. A carboxylesterase domain was found within the amino acid sequences of Ag85A, B, and C, and each protein acted as a mycolyltransferase involved in the final stages of mycobacterial cell wall assembly, as shown by direct enzyme assay and site-directed mutagenesis. Furthermore, the use of an antagonist (6-azido-6-deoxy-α,α′-trehalose) of this activity demonstrates that these proteins are essential and potential targets for new antimycobacterial drugs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference37 articles.

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4. Wolucka B. A., McNeil M. R., de Hoffmann E., Chojnacki T., Brennan P. J., J. Biol. Chem. 269, 23328 (1994);

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