In Vitro Activities of Piperaquine and Other 4-Aminoquinolines against Clinical Isolates of Plasmodium falciparum in Cameroon-Reference-Cited by-同舟云学术

In Vitro Activities of Piperaquine and Other 4-Aminoquinolines against Clinical Isolates of Plasmodium falciparum in Cameroon

Published:2003-04 Issue:4 Volume:47 Page:1391-1394
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Basco Leonardo K.¹,Ringwald Pascal²

Affiliation:

1. Unité de Recherche “Paludologie Afro-tropicale,” Institut de Recherche pour le Développement (IRD)-Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon

2. Cluster of Communicable Diseases, Surveillance and Response, Emerging Public Health Risks including Drug Resistance, World Health Organization, Geneva, Switzerland

Abstract

ABSTRACT The spread of chloroquine-resistant Plasmodium falciparum calls for a constant search for new drugs. The in vitro activity of piperaquine, a new Chinese synthetic drug belonging to the bisquinolines, was evaluated in 103 fresh clinical isolates of P. falciparum in Cameroon, Central Africa, and compared with that of other 4-aminoquinoline and Mannich base derivatives and dihydroartemisinin. Piperaquine was highly active (geometric mean 50% inhibitory concentration, 38.9 nmol/liter; range, 7.76 to 78.3 nmol/liter) and equally active ( P > 0.05) against the chloroquine-sensitive and the chloroquine-resistant isolates. There was a significant but low correlation of response between chloroquine and piperaquine ( r = 0.257, P < 0.05). These results suggest that further development of piperaquine, in combination with dihydroartemisinin, holds promise for use in chloroquine-resistant regions of endemicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.4.1391-1394.2003

Reference27 articles.

1. Chen, L. 1991. Recent studies on antimalarial efficacy of piperaquine and hydroxypiperaquine. Chinese Med. J.104:161-163.

2. Chen, L., F. Y. Qu, and Y. C. Zhou. 1982. Field observations on the antimalarial piperaquine. Chinese Med. J.95:281-286.

3. Deloron, P., J. Le Bras, J. A. Ramanamirija, and P. Coulanges. 1985. Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs. Ann. Trop. Med. Parasitol.79:357-365.

4. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

5. Fan, B., W. Zhao, X. W. Ma, Z. M. Huang, Y. S. Wen, J. Q. Yang, and Z. X. Yang. 1998. In vitro sensitivity of Plasmodium falciparum to chloroquine, piperaquine, pyronaridine and artesunate in Yuxi prefecture of Yunnan province. Chinese J. Parasitol. Parasit. Dis.16:460-462.

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