Novel quinolinepiperazinyl-aryltetrazoles targeting the blood stage of Plasmodium falciparum

Author:

Barmade Mahesh A.1ORCID,Agrawal Prakhar2,Rajput Sweta R.1,Murumkar Prashant R.1ORCID,Rana Bhavika2,Sahal Dinkar2ORCID,Yadav Mange Ram13ORCID

Affiliation:

1. Faculty of Pharmacy, Kalabhavan Campus, The Maharaja Sayajirao University of Baroda, Vadodara-390001, Gujarat, India

2. Malaria Drug Discovery Laboratory, ICGEB, Aruna Asaf Ali Marg, New Delhi-110067, India

3. Research and Development Cell, Parul University, Waghodia Road, P. O. Limda, Vadodara-391760, Gujarat, India

Abstract

This study offers compounds (66 and 75) as a new class of antimalarials, which are active against ACT-resistant strains of the Plasmodium and target several proteins of malaria parasite including the PfGAP50 protein.

Funder

University Grants Commission

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Reference72 articles.

1. Malaria: Biology and Disease

2. World Health Organization , World Malaria Report , 2022 , (Accessed on May 2023, https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2022 )

3. “Big Three” Infectious Diseases: Tuberculosis, Malaria and HIV/AIDS

4. Antimalarial drug resistance

5. Evidence of Artemisinin-Resistant Malaria in Africa

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