Novel quinolinepiperazinyl-aryltetrazoles targeting the blood stage of <i>Plasmodium falciparum</i>-Reference-Cited by-同舟云学术

Novel quinolinepiperazinyl-aryltetrazoles targeting the blood stage of Plasmodium falciparum

Published:2024 Issue: Volume: Page:
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Barmade Mahesh A.¹^ORCID,Agrawal Prakhar²,Rajput Sweta R.¹,Murumkar Prashant R.¹^ORCID,Rana Bhavika²,Sahal Dinkar²^ORCID,Yadav Mange Ram¹³^ORCID

Affiliation:

1. Faculty of Pharmacy, Kalabhavan Campus, The Maharaja Sayajirao University of Baroda, Vadodara-390001, Gujarat, India

2. Malaria Drug Discovery Laboratory, ICGEB, Aruna Asaf Ali Marg, New Delhi-110067, India

3. Research and Development Cell, Parul University, Waghodia Road, P. O. Limda, Vadodara-391760, Gujarat, India

Abstract

This study offers compounds (66 and 75) as a new class of antimalarials, which are active against ACT-resistant strains of the Plasmodium and target several proteins of malaria parasite including the PfGAP50 protein.

Funder

University Grants Commission

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00417A

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