Caspofungin Activity against Clinical Isolates of Fluconazole-Resistant Candida-Reference-Cited by-同舟云学术

Caspofungin Activity against Clinical Isolates of Fluconazole-Resistant Candida

Published:2003-12 Issue:12 Volume:41 Page:5729-5731
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Pfaller Michael A.¹²,Messer Shawn A.¹,Boyken Linda¹,Rice Cassie¹,Tendolkar Shailesh¹,Hollis Richard J.¹,Diekema Daniel J.¹³

Affiliation:

1. Departments of Pathology

2. Epidemiology

3. Medicine, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa

Abstract

ABSTRACT A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC ≥ 64 μg/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 μg/ml; 99% of the MICs were ≤2 μg/ml).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.41.12.5729-5731.2003

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