mecA - blaZ Corepressors in Clinical Staphylococcus aureus Isolates-Reference-Cited by-同舟云学术

mecA - blaZ Corepressors in Clinical Staphylococcus aureus Isolates

Published:2003-04 Issue:4 Volume:47 Page:1460-1463
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rosato Adriana E.¹,Kreiswirth Barry N.²,Craig William A.¹,Eisner William²,Climo Michael W.¹³,Archer Gordon L.¹⁴

Affiliation:

1. Departments of Medicine

2. the Public Health Research Institute, Newark, New Jersey

3. Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia

4. Microbiology and Immunology, Medical College of Virginia Campus of Virginia Commonwealth University

Abstract

ABSTRACT The presence and nucleotide sequences of the two mecA repressors, mecI and blaI , were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI , while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI ( P < 0.05). Among 22 additional isolates that did not contain blaI , all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.47.4.1460-1463.2003

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