Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection-Reference-Cited by-同舟云学术

Impact of Micropolymorphism Outside the Peptide Binding Groove in the Clinically Relevant Allele HLA-C*14 on T Cell Responses in HIV-1 Infection

Published:2022-05-25 Issue:10 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chikata Takayuki¹,Paes Wayne²,Kuse Nozomi¹,Partridge Thomas²,Gatanaga Hiroyuki¹³,Zhang Yu¹,Kuroki Kimiko⁴,Maenaka Katsumi⁴,Ternette Nicola²^ORCID,Oka Shinichi¹³,Borrow Persephone²,Takiguchi Masafumi¹^ORCID

Affiliation:

1. Tokyo Laboratory and Division of International Collaboration Research, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan

2. Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

3. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan

4. Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

Abstract

Some human leukocyte antigen (HLA) class I alleles are associated with good clinical outcomes in HIV-1 infection and are called protective HLA alleles. Identification of T cell epitopes restricted by protective HLA alleles can give important insight into virus-immune system interactions and inform design of immune-based prophylactic/therapeutic strategies.

Funder

HHS | National Institutes of Health

Japan Agency for Medical Research and Development

MEXT | Japan Society for the Promotion of Science

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00432-22

Reference49 articles.