A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1-Reference-Cited by-同舟云学术

A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1

Published:2007-08-17 Issue:5840 Volume:317 Page:944-947
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fellay Jacques¹²³⁴⁵,Shianna Kevin V.¹²³⁴⁵,Ge Dongliang¹²³⁴⁵,Colombo Sara¹²³⁴⁵,Ledergerber Bruno¹²³⁴⁵,Weale Mike¹²³⁴⁵,Zhang Kunlin¹²³⁴⁵,Gumbs Curtis¹²³⁴⁵,Castagna Antonella¹²³⁴⁵,Cossarizza Andrea¹²³⁴⁵,Cozzi-Lepri Alessandro¹²³⁴⁵,De Luca Andrea¹²³⁴⁵,Easterbrook Philippa¹²³⁴⁵,Francioli Patrick¹²³⁴⁵,Mallal Simon¹²³⁴⁵,Martinez-Picado Javier¹²³⁴⁵,Miro José M.¹²³⁴⁵,Obel Niels¹²³⁴⁵,Smith Jason P.¹²³⁴⁵,Wyniger Josiane¹²³⁴⁵,Descombes Patrick¹²³⁴⁵,Antonarakis Stylianos E.¹²³⁴⁵,Letvin Norman L.¹²³⁴⁵,McMichael Andrew J.¹²³⁴⁵,Haynes Barton F.¹²³⁴⁵,Telenti Amalio¹²³⁴⁵,Goldstein David B.¹²³⁴⁵

Affiliation:

1. Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.

2. Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA.

3. Institute of Microbiology, University Hospital Center; and University of Lausanne, 1011 Lausanne, Switzerland.

4. Division of Infectious Diseases, University Hospital, 8091 Zürich, Switzerland.

5. Clinic of Infectious Diseases, Istituto di Ricovero e Cura a Carattere Scientifico, San Raffaele Hospital, 20127 Milan, Italy.

Abstract

Understanding why some people establish and maintain effective control of HIV-1 and others do not is a priority in the effort to develop new treatments for HIV/AIDS. Using a whole-genome association strategy, we identified polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection. One of these is found within an endogenous retroviral element and is associated with major histocompatibility allele human leukocyte antigen ( HLA )– B*5701 , whereas a second is located near the HLA-C gene. An additional analysis of the time to HIV disease progression implicated two genes, one of which encodes an RNA polymerase I subunit. These findings emphasize the importance of studying human genetic variation as a guide to combating infectious agents.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Genomics meets HIV-1

2. Human genes that limit AIDS

3. Host genetics of HIV-1 susceptibility

4. The Influence of HLA Genotype on AIDS

5. Using Mutual Information to Measure the Impact of Multiple Genetic Factors on AIDS

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