Histatin-Derived Monomeric and Dimeric Synthetic Peptides Show Strong Bactericidal Activity towards Multidrug-Resistant Staphylococcus aureus In Vivo-Reference-Cited by-同舟云学术

Histatin-Derived Monomeric and Dimeric Synthetic Peptides Show Strong Bactericidal Activity towards Multidrug-Resistant Staphylococcus aureus In Vivo

Published:2007-09 Issue:9 Volume:51 Page:3416-3419
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Welling Mick M.¹,Brouwer Carlo P. J. M.²,van ′t Hof Wim³,Veerman Enno C. I.³,Amerongen Arie V. Nieuw³

Affiliation:

1. Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands

2. R&D, AM-Pharma, Bunnik, the Netherlands

3. Academic Centre for Dentistry Amsterdam (ACTA), Department of Oral Biochemistry, Amsterdam, the Netherlands

Abstract

ABSTRACT Homodimerization of histatin-derived peptides generally led to improved bactericidal activity against Staphylococcus aureus in vitro. In vivo, monomers and dimers were equally active in killing bacteria in mice with a soft tissue infection. Altogether, these peptides are promising compounds for the development of novel therapeutics against infections with drug-resistant bacteria.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00196-07

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