In Vitro Activity of the Histatin Derivative P-113 against Multidrug-Resistant Pathogens Responsible for Pneumonia in Immunocompromised Patients-Reference-Cited by-同舟云学术

In Vitro Activity of the Histatin Derivative P-113 against Multidrug-Resistant Pathogens Responsible for Pneumonia in Immunocompromised Patients

Published:2005-03 Issue:3 Volume:49 Page:1249-1252
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Giacometti Andrea¹,Cirioni Oscar¹,Kamysz Wojciech²,D'Amato Giuseppina¹,Silvestri Carmela¹,Prete Maria Simona Del¹,Licci Alberto¹,Riva Alessandra¹,Łukasiak Jerzy²,Scalise Giorgio¹

Affiliation:

1. Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche, Ancona, Italy

2. Faculty of Pharmacy, Medical University of Gdansk, Gdansk, Poland

Abstract

ABSTRACT The in vitro activity of the histatin derivative P-113, alone or combined with eight antibiotics, was investigated against multidrug-resistant strains isolated from clinical specimens of immunocompromised patients with pneumonia. The gram-negative isolates were susceptible to P-113. S. aureus showed less susceptibility. Synergy was demonstrated when P-113 was combined with beta-lactams against gram-negative organisms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.3.1249-1252.2005

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