Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy-Reference-Cited by-同舟云学术

Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy

Published:2007-03 Issue:3 Volume:75 Page:1507-1511
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

D'Ávila Heloisa¹,Almeida Patrícia E.¹,Roque Natália R.¹,Castro-Faria-Neto Hugo C.¹,Bozza Patrícia T.¹

Affiliation:

1. Laboratório de Imunofarmacologia, Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21045-900, Brazil

Abstract

ABSTRACT An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01326-06

Reference27 articles.

1. Adamko, D. J., S. O. Odemuyiwa, M. Vethanayagam, and R. Moqbel. 2005. The rise of the phoenix the expanding role of the eosinophil in health and disease. Allergy60:13-22.

2. Bandeira-Melo, C., M. Phoofolo, and P. F. Weller. 2001. Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. J. Biol. Chem.276:22779-22787.

3. Bozza, P. T., H. C. Castro-Faria-Neto, C. Penido, A. P. Larangeira, M. das Gracas, M. O. Henriques, P. M. Silva, M. A. Martins, R. R. dos Santos, and R. S. Cordeiro. 1994. Requirement for lymphocytes and resident macrophages in LPS-induced pleural eosinophil accumulation. J. Leukoc. Biol.56:151-158.

4. Bozza, P. T., R. C. N. Melo, and C. Bandeira-Melo. 2007. Leukocyte lipid bodies regulation and function: contribution to allergy and host defense. Pharmacol. Ther.113:30-49.

5. Bulut, Y., E. Faure, L. Thomas, O. Equils, and M. Arditi. 2001. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J. Immunol.167:987-994.

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Eosinophils as modulators of host defense during parasitic, fungal, bacterial, and viral infections;Journal of Leukocyte Biology;2024-08-13

2. The function of CD36 in Mycobacterium tuberculosis infection;Frontiers in Immunology;2024-05-31

3. Inflammatory Patterns Associated with Legionella in HIV and Pneumonia Coinfections;Pathogens;2024-02-14

4. An Andrographis paniculata Burm. Nees extract standardized for three main Andrographolides prevents house dust mite-induced airway inflammation, remodeling, and hyperreactivity by regulating Th1/Th2 gene expression in mice;Journal of Ethnopharmacology;2024-01

5. The regulatory role of eosinophils in viral, bacterial, and fungal infections;Clinical and Experimental Immunology;2022-04-25