Affiliation:
1. Chemical Process Improvement Department, Lederle Laboratories, American Cyanamid Company, Pearl River, New York
Abstract
9α-Fluorohydrocortisone is hydroxylated by
Streptomyces roseochromogenes
in the 16α-, the 2β-, and in both the 16α- and 2β- positions. 16α-Hydroxylation appears to be the more predominant and rapid pathway of transformation. The degree of 2β-hydroxylation is dependent upon the strain used and may be increased to the point of its being a major route or virtually eliminated by the proper selection of isolates.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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