Autoradiographic Localization of [ 3 H]Gentamicin in the Proximal Renal Tubules of Mice-Reference-Cited by-同舟云学术

Autoradiographic Localization of [ 3 H]Gentamicin in the Proximal Renal Tubules of Mice

Published:1979-01 Issue:1 Volume:15 Page:131-133
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kuhar Michael J.¹,Mak Linda L.²,Lietman Paul S.¹²

Affiliation:

1. Department of Pharmacology and Experimental Therapeutics The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

2. Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Abstract

The site of localization of [ 3 H]gentamicin within mouse kidney is shown to be the proximal renal tubule by coincidence of the radioactivity, as visualized by autoradiography, and the mucopolysaccharide-rich microvilli characteristic of proximal convoluted tubules, as visualized by histochemical staining.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.15.1.131

Reference14 articles.

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3. Concentrations of gentamicin and amikacin in human kidneys;Edwards C. Q.;Antimicrob. Agents Chemother.,1976

4. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats;Fabre J.;Kidney Int.,1976

5. Flandre O. and M. Kamon. 1967. Experimental study of the nephrotoxicity of gentamicin in rats p. 47-61. In Gentamicin: First International Symposium on Gentamicin. Schwabe and Co. Basel. NOTES 133

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