Therapeutic drug monitoring of antimicrobials

Author:

Balakrishnan Indran12,Shorten Robert J23

Affiliation:

1. Department of Medical Microbiology, Royal Free London NHS Foundation Trust, London, UK

2. Centre for Clinical Microbiology, University College London, Royal Free Campus, London, UK

3. Public Health Laboratory Manchester, Manchester Royal Infirmary, Manchester, UK

Abstract

As pathology services become more centralized and automated, the measurement of therapeutic antimicrobial drugs concentrations is increasingly performed in clinical biochemistry or ‘blood science’ laboratories. This review outlines key groups of antimicrobial agents: aminoglycosides, glycopeptides, antifungal agents and antituberculosis agents, their role in managing infectious diseases, and the reasons why serum concentration measurement is important.

Publisher

SAGE Publications

Subject

Clinical Biochemistry,General Medicine

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