Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog-Reference-Cited by-同舟云学术

Structural Insights into Inhibition of the Acinetobacter-Derived Cephalosporinase ADC-7 by Ceftazidime and Its Boronic Acid Transition State Analog

Published:2020-11-17 Issue:12 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Curtis Brandy N.¹,Smolen Kali A.¹,Barlow Sara J.¹,Caselli Emilia²,Prati Fabio²,Taracila Magdalena A.³⁴,Bonomo Robert A.³⁴⁵⁶⁷,Wallar Bradley J.¹,Powers Rachel A.¹

Affiliation:

1. Department of Chemistry, Grand Valley State University, Allendale, Michigan, USA

2. Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

3. Louis Stokes Cleveland Veterans Affairs Medical Center, Research Service, Cleveland, Ohio, USA

4. Case Western Reserve University, Department of Medicine, Cleveland, Ohio, USA

5. Case Western Reserve University, Department of Pharmacology, Cleveland, Ohio, USA

6. CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio, USA

7. Case Western Reserve University, Department of Biochemistry, Cleveland, Ohio, USA

Abstract

Extended-spectrum class C β-lactamases have evolved to rapidly inactivate expanded-spectrum cephalosporins, a class of antibiotics designed to be resistant to hydrolysis by β-lactamase enzymes. To better understand the mechanism by which A cinetobacter - d erived c ephalosporinase-7 (ADC-7), a chromosomal AmpC enzyme, hydrolyzes these molecules, we determined the X-ray crystal structure of ADC-7 in an acyl-enzyme complex with the cephalosporin ceftazidime (2.

Funder

Cleveland Department of Veterans Affairs

Michigan Economic Development Corporation and the Michigan Technology Tri-Corridor

Department of Life Sciences, University of Modena and Reggio Emilia

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01183-20

Reference41 articles.

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