Antioxidant function of fungal melanin

Author:

Jacobson E S1,Tinnell S B1

Affiliation:

1. Research Service, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249.

Abstract

Polyphenols have been implicated in the virulence and oxidant resistance of Cryptococcus neoformans. Although monomeric polyphenols did not protect against the prooxidant, plumbagin, polymeric dopamine-melanin conferred resistance both to hypochlorite and to permanganate. The physiologic antioxidant capacity conferred by melanin was found to be 21.3 x 10(-15) mole-equivalents per cell, a value which approximates oxidant production by stimulated macrophages.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference19 articles.

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3. Pathogenicity and virulence of wild-type and melanin-deficient Wangiella dermatitidis;Dixon D. M.;J. Med. Vet. Mycol.,1987

4. Hydrogen peroxide release by alveolar macrophages from sarcoid patients and by alveolar macrophages from normals after exposure to recombinant interferons alpha A, beta and gamma and 1,25- dihydroxyvitamin D3;Fels A.;J. Clin. Invest.,1987

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