Affiliation:
1. Research Service, McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249.
Abstract
Polyphenols have been implicated in the virulence and oxidant resistance of Cryptococcus neoformans. Although monomeric polyphenols did not protect against the prooxidant, plumbagin, polymeric dopamine-melanin conferred resistance both to hypochlorite and to permanganate. The physiologic antioxidant capacity conferred by melanin was found to be 21.3 x 10(-15) mole-equivalents per cell, a value which approximates oxidant production by stimulated macrophages.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
182 articles.
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