Affiliation:
1. Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey
Abstract
Demain
, A. L. (Merck Sharp & Dohme Research Laboratories, Rahway, N.J.),
Joanne F. Newkirk, and D. Hendlin
. Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media. J. Bacteriol.
85:
339–344. 1963.—Chemically defined media were developed for production of cephalosporin C by
Cephalosporium
sp. In such media, the requirement for methionine can be satisfied by norleucine. Further stimulation of antibiotic production was obtained with the lysine derivatives ε-
N
-acetyl-
l
-lysine and ε-aminocaproic acid but not with lysine itself. Also inactive were α-aminoadipic and ketoadipic acids. Other lysine derivatives were found to inhibit cephalosporin C production at 0.01
m
. The final medium supported the production of approximately 0.5 g of cephalosporin C per liter of medium.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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