Group B Streptococcal Pilus Proteins Contribute to Adherence to and Invasion of Brain Microvascular Endothelial Cells-Reference-Cited by-同舟云学术

Group B Streptococcal Pilus Proteins Contribute to Adherence to and Invasion of Brain Microvascular Endothelial Cells

Published:2007-02-15 Issue:4 Volume:189 Page:1464-1467
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Maisey Heather C.¹,Hensler Mary¹,Nizet Victor¹,Doran Kelly S.¹

Affiliation:

1. Department of Pediatrics, Division of Pharmacology & Drug Discovery, University of California, San Diego School of Medicine, La Jolla, California 92093

Abstract

ABSTRACT Surface filamentous structures known as pili have been discovered recently in the gram-positive streptococcal pathogens that cause invasive disease in humans, including group B Streptococcus (GBS). We show that two GBS proteins involved in pilus formation, encoded by pilA and pilB , also facilitate the interaction of this important agent of central nervous system infection with endothelial cells of the human blood-brain barrier.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.01153-06

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