Glutamate Dehydrogenase (GdhA) of Streptococcus pneumoniae Is Required for High Temperature Adaptation

Author:

Gazioglu Ozcan1,Kareem Banaz O.12,Afzal Muhammad3,Shafeeq Sulman3ORCID,Kuipers Oscar P.3ORCID,Ulijasz Andrew T.4ORCID,Andrew Peter W.1,Yesilkaya Hasan1ORCID

Affiliation:

1. Department of Respiratory Sciences, University of Leicester, Leicester, United Kingdom

2. Department of Medical Laboratory Science, College of Medicals and Applied Sciences, University of Charmo, Chamchamal, Iraq

3. Molecular Genetics, University of Groningen, Groningen, The Netherlands

4. Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA

Abstract

During its progression from the nasopharynx to other sterile and nonsterile niches of its human host, Streptococcus pneumoniae must cope with changes in temperature. We hypothesized that the temperature adaptation is an important facet of pneumococcal survival in the host.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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