Genome Plasticity of agr -Defective Staphylococcus aureus during Clinical Infection-Reference-Cited by-同舟云学术

Genome Plasticity of agr -Defective Staphylococcus aureus during Clinical Infection

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Altman Deena R.¹²^ORCID,Sullivan Mitchell J.²,Chacko Kieran I.²,Balasubramanian Divya³,Pak Theodore R.²^ORCID,Sause William E.³,Kumar Krishan⁴,Sebra Robert²⁵,Deikus Gintaras²⁵,Attie Oliver²,Rose Hannah⁴,Lewis Martha²,Fulmer Yi⁴,Bashir Ali²,Kasarskis Andrew²⁵,Schadt Eric E.²⁵,Richardson Anthony R.⁶,Torres Victor J.³,Shopsin Bo³⁴,van Bakel Harm²⁵^ORCID

Affiliation:

1. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

2. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

3. Department of Microbiology, New York University School of Medicine, New York, New York, USA

4. Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA

5. Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

6. Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Abstract

Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when treatment conditions are optimal according to experimental protocols. Adapted subclones, such as those bearing mutations that attenuate agr -mediated virulence activation, are associated with persistent infection and patient mortality.

Funder

HHS | National Institutes of Health

New York State Department of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00331-18

Reference90 articles.

1. Convergent Adaptation in the Dominant Global Hospital Clone ST239 of Methicillin-Resistant Staphylococcus aureus

2. Production of an Attenuated Phenol-Soluble Modulin Variant Unique to the MRSA Clonal Complex 30 Increases Severity of Bloodstream Infection